Identification of genes dependent on the MADS box transcription factor SrfA in Dictyostelium discoideum development.
نویسندگان
چکیده
Analysis of microarrays containing 6,345 Dictyostelium discoideum genes has identified 21 whose expression is dependent on the MADS box transcription factor SrfA. In wild-type cells, all of these genes are induced late in development. At least four of them are necessary for proper spore differentiation, stability, and/or germination.
منابع مشابه
Dictyostelium discoideum developmentally regulated genes whose expression is dependent on MADS box transcription factor SrfA.
The MADS box transcription factor SrfA is required for spore differentiation in Dictyostelium discoideum. srfA null strains form rounded spores that do not resist adverse environmental conditions. Five genes whose expression is dependent on SrfA have been isolated by differential hybridization. One of these genes, sigC, is identical to phg1b, previously characterized in mutants with altered adh...
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Cell differentiation and morphogenesis are tightly regulated during sporulation in the lower eukaryote Dictyostelium discoideum. The control of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is essential to coordinate these processes. Several signal transduction pathways are being recognized that lead to the regulation of intracellular cAMP levels. However, very little...
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متن کاملVolume Contents (E-only pages)
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ورودعنوان ژورنال:
- Eukaryotic cell
دوره 3 2 شماره
صفحات -
تاریخ انتشار 2004